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Description
Defecatory dysfunction (33.3%), delayed gastric/bowel/colonic transit (26.3%), various food intolerances, unexplained abdominal pain (both 16%), and dysphagia were less common and did not show any sex and age bias

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Biochemically, rats exposed to nicotine (2.5 mL/kg) showed a significant increase of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum due to hepatocyte cell death/damage
