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Clinical studies have also confirmed that prenatal glucocorticoid (GC) exposure not only sensitizes the HPA axis response to painful stress of a heel-stick in full-term infants, but also increases the stress reactivity of 10-year-old-children to a standard psychological stress test [44, 45]

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If the DNA repair mechanisms are faulty, or if DNA damage is too extensive, elevated p53 can lead to apoptosis (programmed cell death) (see Figure 2)
