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Following menthol administration, male rats self-administered more intravenous nicotine infusions and increased their motivation to obtain nicotine (151), and male mice self-administered electronic cigarette vapor containing menthol and nicotine at greater levels than nicotine vapor alone (61)

Ethics declarations Ethics approval and consent to participate This simulation model-based research was approved by the Mass General Brigham Human Research Committee (Protocol #2019P001772)

Oxford University Press: 9

Intent and Stewardship In Christian ethics, the intention behind an act is often as important as the act itself