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These are the International Agency for Research on Cancer (IARC) and the The IARC, which is part of the World Health Organization (WHO), has reviewed over 1,000 potential carcinogens
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Theres a family of transporters called P-glycoprotein that act like gatekeepers at both the gut lumen and blood-brain barrier, regulating how drugs get into and out of the systemic vasculature and the brain, respectively
