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The decision sparked outrage among many public health officials and lawmakers who cited the negative health impacts and racial health disparities of smoking that will worsen in the absence of federal action

One clinical laboratory study examined the effects of methoxsalen, a CYP2A6 inhibitor, on cigarette smoking and found that methoxsalen in combination with oral nicotine decreases carbon monoxide exposure, smoking rate, latency between lighting the first and second cigarettes, and number of puffs taken (Sellars et al., 2000) compared to a placebo-placebo condition

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