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At least three major cigar products little cigars, large cigars, and cigarillos exist in the category

Among these, N-nitrosodimethylamine (NDMA) is a potent hepatocarcinogen that induces DNA alkylation, oxidative stress, and promotes liver fibrosis, ultimately facilitating HCC development [26]

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July 1958 Consumers Digest Tar Measurements and Comparisons Companies successfully reduced tar and nicotine in all brands as seen by the sales-weighted tar and nicotine content decreasing 40% between mid 1957 and the end of 1959