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Simmons as B.R., Nick's boss Robert Duvall as the Captain, founder of the Academy for Tobacco Studies Kim Dickens as Jill Naylor, Nick's ex-wife Connie Ray as Pearl Todd Louiso as Ron Goode Marianne Muellerleile as Joey's school teacher Dennis Miller as himself Melora Hardin as Interviewer Daniel Travis as Brad, Jill's current partner Director Jason Reitman asked many of his prospective actors and actresses to be in the film by writing each of them a personal letter

Greater London House is home to the British Heart Foundation, Young & Rubicam and Revlon, but the biggest occupier is online fashion and beauty retailer ASOS

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Cleveland Clinics health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards