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Heart rate was a factor in this study finding that cigarettes and chewing tobacco had the highest bpm (36 and 35), oral tobacco was slightly lower (29), and nicotine gum came in the lowest (19)

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Sedation is primarily done with benzodiazepines, such as midazolam (Midazolam 1 mg/ml) or diazepam (Stesolid 5 mg/ml), and secondly with propofol (Diprivan 20 mg/ml)

1985 Age-related factors in carcinogenesis Vol
