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Description
Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures

Tobacco harm reduction may be part of this strategy by reducing exposure to the greatest source of risk: tobacco combustion. The authors also call for prospective studies to better understand how smoking behaviours evolve in older populations and how transitions between smoking, vaping, dual use, and complete cessation influence healthy ageing

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