can smoking too many cigarettes make you feel sick Smoking: Effects, Risks, Diseases, Quitting & Solutions The Many Dangers of Tobacco

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Abbreviations aHR Adjusted hazard ratio ALT Alanine aminotransferase ALD Alcohol-related liver disease CV Cardiovascular disease CYP1A2 Cytochrome P450 1A2 HBV Hepatitis B virus HCV Hepatitis C virus HCC Hepatocellular carcinoma HR Hazard ratio HSCs Hepatic stellate cells IL Interleukin LT Liver transplantation MASLD Metabolic dysfunction-associated steatotic liver disease MAPKs Mitogen-activated protein kinases MetS Metabolic syndrome NDMA N-nitrosodimethylamine NF-B Nuclear factor-kappa B NHANES National Health and Nutrition Examination Survey NRT Nicotine replacement therapy OR Odds ratio PAHs Polycyclic aromatic hydrocarbons PBC Primary biliary cholangitis PG Propylene glycol ROS Reactive oxygen species RR Relative risk TERT Telomerase reverse transcriptase TGF-1 Transforming growth factor beta 1 TNF- Tumor necrosis factor alpha VG Vegetable glycerin 7-nAChR 7-Nicotinic acetylcholine receptor 2-AR 2-Adrenergic receptor Authors' contribution GE wrote the manuscript

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