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Though most addictive drugs at high doses can cause physiological symptoms that lead to unconsciousness or even death, nicotine is unique in making people physically ill when inhaled or ingested in large quantities

For example, a 60-year-old smoker may have the health profile of a 70-year-old non-smoker

Influential public health research such as the Cochrane Review 2022 have widely agreed that heated tobacco products expose users to lower levels of key toxins and carcinogens than are otherwise found in combustible tobacco smoke

The Highly Addictive Nature of Cocaine Cocaine affects the brain by increasing the levels of dopamine, a neurotransmitter associated with pleasure and reward