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For further analysis of this heterogeneity, we used a funnel plot as a subjective assessment and conducted subgroup analysis, sensitivity analysis, and univariate meta-regression for objective assessment of the aetiologies of heterogeneity

Neuroadaptations in these pathways are associated with occurrence of depressed mood, agitation and anxiety shortly after a cigarette is smoked (Benowitz, Hukkanen and Jacob, 2009)

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