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Besides the induction of inflammatory macrophages, nicotine treatments promote the M2 polarization, reduces the secretion of several proinflammatory cytokines in macrophages, and suppresses the alveolar macrophages to present the inhaled antigen to lymphocytes [130, 131]

doi: 10.1080/00048670701392809 [27] Elkader AK, Brands B, Selby P & Sproule BA

However, the World Health Organisation suggests that e-cigarettes cannot be considered as a viable method to quit smoking, due to a lack of evidence [7, 95]

When tobacco smoke is inhaled via cigarettes or cigars, nicotine is absorbed through the lungs into the bloodstream and reaches the brain in 10 to 20 seconds