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Acknowledgements This work was supported partially by the Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan, by Kaohsiung Medical University Research Center Grant (KMU-TC109A01-1) and by Kaohsiung Municipal Siaogang Hospital (S-108-017)