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From there, tobacco production spread from the Tidewater area to the Blue Ridge Mountains, especially dominating the agriculture of the Chesapeake region. [1] It became such a huge commodity that the Virginia House of Burgesses made it a requirement for tobacco to be inspected, and directed the construction of warehouses and port towns where tobacco would be brought by planters

19 Multiple studies have confirmed and extended the association of variants in these and related genes with lung cancer