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Acknowledgements This study was supported in part by NIDA grants: 1R56DA036556, R01DA029845, R01DA030394, R01HL102119, and R21DA032022, Natural Science Foundation of Zhejiang Province Grant LZ15H180001, the program for professor of special appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Hangzhou Qianjiang Endowed Professor Program and the Youth 1000 Talent Program of China