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Beyond Cigarettes: The Risks of Non-Cigarette Nicotine Products and Implications for Tobacco Control BACKGROUND Whereas much is known about the effects of tobacco use, the current state of knowledge regarding non-cigarette nicotine products, such as electronic nicotine delivery systems (e-cigarettes and other vaping devices), water pipe/hookah, smokeless tobacco, pipes, cigars, little cigars, and cigarillos, that do not contain tobacco is not robust enough to yield a definitive consensus regarding their relative risks and benefits

Moreover, by the end of the XIX century nicotines empirical formula was described (1843, Louis-Henri-Frederic Melsens), the structure was discovered (1893, Adolf Pinner) and in 1904 pure nicotine was first synthesized by a Swiss Ame Pictet

The nature of the attacks helped confirm the Americans believed they were fighting a fanatical enemy
