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According to Ken Marians, a DNA replication expert at SKI, an abundance of G-to-T tranversions in DNA is a hallmark of smoking-induced damage and has been dubbed the smoking signature. Different types of environmental factors cause different types of mutations

Furthermore, in line with the direct interaction with nAChRs, nicotine indirectly affects the renin-angiotensin system

Knippschild, U

Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53
