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Over time, the brain begins to rely on nicotine to maintain normal function

Why Some People Quit Easier Than Others Genetic factors significantly influence cessation success rates and optimal treatment selection: Metabolism Rate : Slow nicotine metabolizers often respond better to nicotine replacement therapy and may need lower doses, while fast metabolizers might benefit from combination therapies or longer treatment duration

The irony is that increased regulation on tobacco in particular have essentially created a lasting moat, or a barrier to entry, that makes it harder for new entrants into the market

And similarly, we still need to learn how much vaping use equals how much eye damage