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This is a man-made epidemic caused by cigarette smoking

GSH is found predominantly in the cytosol (~90%), with smaller but vital pools in mitochondria and the endoplasmic reticulum

S., Singh S., and Kumar R., Design, Synthesis, Biological Evaluation of 3,5Diaryl4,5Dihydro1HPyrazole Carbaldehydes as NonPurine Xanthine Oxidase Inhibitors: Tracing the Anticancer Mechanism via Xanthine Oxidase Inhibition, Bioorganic Chemistry 107 (2021): 104620, 10.1016/j.bioorg.2020.104620

[124] reported that red-fleshed apples showed greater antioxidant activities, phenolics, and flavonoid content than regular fuji apples