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Ample genetic evidence proves Mc4r signaling to be a critical component of the body-weight regulation system

A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

BMI Requirements: Semaglutide is generally not recommended for individuals with a BMI below 27 unless they have an obesity-related medical condition