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Phosphorylation of eIF2- results in global inhibition of mRNA translation

Other enzymes/enzyme systems, e.g., selenium-containing glutathione peroxidases (GPx) or peroxiredoxins (Prdx), use GSH to reduce various peroxides and hydroperoxides

Instead, it is a combination of diet and environment, which interacts with increased susceptibility due to the MTHFR variants