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Among these, Claudin-5, Occludin, and zonula occludens-1 (ZO-1) are central to maintaining the structural integrity and function of tight junctions (61).Claudin-5, a principal protein in inter-endothelial tight junctions, determines BBB selective permeabilitys (62)

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Allergy avoidance: Removal of excipients, dyes, or allergens
