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Description
The accumulation of cytoplasmic TDP-43 aggregates is considered a late-stage event in neurodegeneration

This is iron-dependent, which is different from apoptosis, programmed necrosis, and other known forms of cell death, and is usually accompanied by a massive accumulation of ROS, oxidative stress)
Korkushko OV, et al

2023.02428.RESTART (to T.F.)