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147 This implies a transcriptional response that is tuned to change in bioavailable or weakly chelated [Zn] of 10 12 M to 10 10 M (corresponding to one log on either side of K d S which covers 1090% of a canonical transcriptional response) (Figure 8A)

However, due to the progressive and wide-spread nature of ET, early stimulation may not be enough

Such subtle but widespread alterations of conduction velocity, which would perturb network synchronization in the brain, could be the substrate of frequent and disabling non-focal MS symptoms such as fatigue, mood disorders and cognitive decline (Kalb et al., 2019

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