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200 M cystine (Sigma Aldrich) was added to the base medium to form the full complement medium

This will favour assay compression, automation, and standardised pre-analytics over bespoke deep profiling, with discovery-grade multi-omics serving primarily to identify stable programmes that can be distilled into targeted, deployable panels [61, 462]

160,161 As opioid agonists, furthermore, methadone and buprenorphine do not abort opioid tolerance or dependency so much as they offer safer, more sustainable and humane options for addiction maintenance than other opioid preparations