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Description
In multiple myeloma, CB-839 as a single agent was not efficient, but the main purpose of the research was the discovery of the mechanisms that help to overcome resistance to carfilzomib
Although induced by carcinogens, foci of cellular alteration can be found as non-neoplastic end stage lesions and not all foci can be related to carcinogens (Peraino et al
Am J Respir Cell Mol Biol 60:2840

These include incomplete knowledge of the underlying mechanisms, the need to explore how epilepsy type and nutritional status interact, variability in the effectiveness of dietary therapies, long-term effects and sustainability of interventions, the role of the gut microbiota, and tailored strategies for special populations
