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With persistent hypoxia, HIF-1 remains activated and drives abnormal expression of downstream genes, including heme oxygenase-1 ( H O -1 ) (Zhai et al., 2023)
[79] showed that TGF- functions as a down-regulator of the expression of the enzyme GCL, the rate-limiting step enzyme involved in the synthesis of GSH as mentioned earlier, which negatively effects the production of GSH
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