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Exercise stimulates BDNF expression through activation of PGC-1 and the cyclic AMP response element-binding protein (CREB) pathway, which enhances synaptic remodeling and neurogenesis, particularly in the hippocampus and prefrontal cortex [129]
A.PalA.et al (2012)
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Beta-oxidation and beta-3 adrenergic signaling are selectively stimulated, allowing controlled studies of lipid metabolism and energy regulation
