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doi: 10.1152/japplphysiol.00990.2016
Such mechanisms include the regulation of the hypothalamic-pituitary-testicular axis, which controls testosterone and sperm production, and the modulation of inflammatory pathways, where gut imbalances can cause endotoxemia and disrupt the blood-testis barrier, as shown by authors [231]
Skin barrier defect in atopic dermatitis: Increased permeability of the stratum corneum using dimethyl sulfoxide and theophylline
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