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The microbiota can communicate via the brain-gut axis and the host immune system through their enzymes and cell wall components

First principles for therapy design Therapy design should follow three first principles: target the source before the sink, prioritizing isoform- or site-specific modulation of NOX enzymes, mitochondrial ROS sites, ER oxidoreductases, or iron handling rather than indiscriminate scavenging that can blunt physiological signalling (Sies et al

Extracellular tissues can also incorporate ammonia into glutamine via transaminases, with glutamine then transported through the circulatory system to the liver to participate in the urea cycle (101)

Conversely, artificial activation of the sympathetic nerves using genetically engineered cell receptors induced melanocyte stem cell loss and hair graying, mimicking the effects of stress