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Description
Since TMAO synthesis is predominantly regulated by gut microbiota, treatment options for managing and lowering TMAO levels center on dietary adjustments, probiotic and prebiotic therapies, antibiotics, exercise, and lifestyle changes [88]

To understand how these distal regulatory elements specifically regulate gene expression, more detailed functional validation and mechanistic studies are required

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Taken together, while the observed trend toward higher circulating L-carnitine in the pomegranate condition warrants further investigation, the data presented here do not allow us to distinguish between enhanced absorption versus delayed microbial catabolism as contributing factors
