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Compounds like carnitine, derived from the amino acids lysine and methionine, help transport fatty acids into cells to be used as energy sources

To create a hypertonic medullary interstitium, adequate function of all the tubular sodium transporters is necessary, for example, NHE3 (type 3 Na+/H+ exchanger), NaPi-2, (type 2 Na-Pi cotransporter), BSC-1 (type 1 bumetanide-sensitive Na-K-2Cl cotransporter), or TSC (thiazide-sensitive cotransporter) in the lumen side of the tubule (mechanism 1)

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Unfortunately, following the conventional application routes, the low brain bioavailability of MEL forms a significant limitation