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Normal tau proteins allow the assembly and the stabilization of the microtubules, whereas hyperphosphorylated tau disrupts microtubules forming NFTs (Iqbal et al., 2009)

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Unlike the relatively stable hormonal environment in men, women experience cyclical variations in 17-estradiol (E2) and progesterone (P4) that directly influence key metabolic processes, including glucose homeostasis, lipid oxidation, amino acid turnover, and mitochondrial bioenergetics [3,4,5]

however, they sometimes gloss over the cost and time commitment
