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Vitamins C and E play a pivotal role in modulating this process by scavenging excess ROS, maintaining glutathione homeostasis, diminishing lipid peroxidation, and mitigating the effects of inflammatory mediators such as IL-6 and TNF-

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The primary outcome of treatment success at week 16, defined as clear or almost clear skin on the Investigators Global Assessment for Chronic Hand Eczema (IGA-CHE), was significantly greater in the delgocitinib cream group compared to standard therapy (20% vs