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The transcriptional profile of the skin microbiota in HL414 was different from other healthy subjects after vitamin B12 supplementation To understand why subject HL414, not others in our healthy cohort, developed acne after vitamin B12 supplementation, we further investigated the specific bacterial transcriptional changes in HL414 compared to the other subjects 14 days after vitamin B12 supplementation

Samples were tested for the presence of AIs (2-androstenol (5-androst-2-en-17-ol), 2-androstenone (5-androst-2-en-17-one), 3-androstenol (5-androst-3-en-17-ol), 3-androstenone (5-androst-3-en-17-one), 4-androstene-3,6,17 trione (6-oxo), aminoglutethimide, anastrozole, androsta-1,4,6-triene-3,17-dione (androstatrienedione), androsta-3,5-diene-7,17-dione (arimistane), exemestane, formestane, letrozole, and testolactone), and anti-estrogenic substance (bazedoxifene, clomiphene, cyclofenil, fulvestrant, ospemifene, raloxifene, tamoxifen, and toremifene) prohibited by WADA