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Furthermore, the regulator of G protein signaling 2 is implicated in the modulation of GPCR signaling, particularly the reduction of Gq-coupled receptor activity, which is associated with bronchoconstriction and inflammation in asthma [173]

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The many faces of B12 deciency include neurologic symptoms such as numbness and tingling in the hands and feet, muscle cramps, dizziness, cognitive disturbances, difficulty walking, erectile dysfunction, as well as fatigue and psychiatric symptoms like depression and even psychosis. In addition to these more spectacular symptoms, B12 deficiency over time is associated with a rise in homocysteine in the blood, an amino acid that, when elevated, leads to a hardening and thickening of artery walls