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Description
Gastrointestinal: Infrequent: abdominal pain, dyspepsia, dysphagia, hiccup

Cell (2017) 168:65769

TNF-, NF-B, IL-1b, AP-1, and Mitogen-activated protein kinases (MAPKs) intermediates get activated after receiving the pro-inflammatory stimuli and release pro-inflammatory chemokines, MMPs, inflammatory enzymes, adhesion molecules, and angiogenic factors resulting in neo-vascularization, arthritic joint destruction and chronic inflammation

B12 is essential for maintaining the normal function of the brain and nervous system
