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Description
Early history: studies linking thiol metabolism to oxidative cell death Reduced glutathione (-L-glutamyl-L-cysteinylglycine, GSH) is an essential intracellular antioxidant synthesized from glutamate, cysteine and glycine in two steps by the ATP-dependent cytosolic enzymes glutamate-cysteine ligase (GCL) and glutathione synthetase (GSS) (Figure 1)

Gazzah A, Bedard PL, Hierro C, et al

Gastroenterology 125:117125

