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The increased inositol-requiring enzyme 1 expression by PFOS, which indicated endoplasmic reticulum (ER) stress activation, was associated with PFOS-mediated autophagy activation that could be attenuated through 4-phenylbutyrate (5 mM, an ER stress inhibitor) and l-Carnitine pretreatment

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Although most included studies did not report significant increases in CK levels, systematic assessment of RML incidence, severity, and recovery under different training intensities and modalities remains insufficient