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Convenience of Injections: Tirzepatide is administered through injections, typically on a weekly basis, making it a convenient treatment option for those who prefer not to take daily oral medications

[DOI] [PubMed] [Google Scholar] Yuan H, Jiang SP, Du YZ, Miao J, Zhang XG, Hu FQ

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Further, several molecules, including tumor necrosis factor alpha (TNF), leptin, -amyloid, delta-sleep inducing peptide (DSIP), and prostaglandin D2 (PGD2) display changes of rhythmic entry into murine CNS ( Bmal1 deficient mice display hyperpermeability and downregulation of platelet-derived growth factor receptor (PDGFR), suggesting a significant role for Bmal1 in pericyte regulation for blood-brain barrier maintenance (Nakazato et al., 2017)