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CEM, Matthews, NC) following Fmoc/t-Bu (Fmoc:Fluorenyl methoxy carbonyl, t-Bu: tertiary-butyl) strategy on Rink amide resin with HBTU ( N,N,N ,N -Tetramethyl- O- (1 H -benzotriazol-1-yl)uranium hexafluorophosphate (OR) O -(Benzotriazol-1-yl)- N,N,N ,N -tetramethyluronium hexafluorophosphate)activator, collidine activator base and 5% piperazine for deprotection

GSH depletion-induced activation of 12/15-LOX can increase cytosolic Ca 2+ via both (1) the import from the extracellular compartment and (2) release from mitochondria and endoplasmic reticulum (Maher et al., 2018)

0.9% Sodium Chloride 100 mL 4

The clinical drug candidate anle138b binds in a cavity of lipidic alpha-synuclein fibrils