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Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion

It has indeed been demonstrated that p300/CBP transcriptional co-activator proteins (two central players in coordinating and integrating multiple signal dependent events with the transcription apparatus [215, 216]) bind to NRF2 in response to OS induced by arsenite and acetylate several Lys residues within the Neh1, the DNA binding region of NRF2, stabilizing it, increasing protein abundance, and promoting NRF2 nuclear localization [146, 214, 217] (Fig

PMID: 177 ZhouPZhangSWangMZhouJ

[DOI] [PMC free article] [PubMed] [Google Scholar] 149.Schapira AH, Gegg ME