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A review highlighted the safety and efficacy of low-dose nicotine treatments, suggesting a promising therapeutic avenue for future studies (Oertel et al., 2023)

In elderly individuals, a six-week structured aerobic regimen was associated with significant reductions in Beck Depression Inventory (BDI) scores, particularly in somatic symptoms, suggesting that physical activity contributes to emotional well-being and mood stabilization [67]

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It might cause a bit of discomfort, but its typically not painful