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The general goal of drug desensitization is to induce tolerance to the drug, allowing a safe continuation of drug therapy
[DOI] [PubMed] [Google Scholar] 200.Zhang HB, Tu XK, Chen Q, Shi SS
Furthermore, the mechanistic understanding of metabolite-mediated epigenetic reprogramming continues to expand, with evidence showing that lactate-induced histone lactylation and itaconate-driven Nrf2 activation can establish and sustain an anti-inflammatory macrophage phenotype, opening avenues for durable immunomodulation (78, 82, 84)
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