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The JAKSTAT is a critical pathway that responds to and mediates inflammatory molecules, which is significantly upregulated in glomerular cells of DN patients and is negatively associated with eGFR

In keeping with the longevity of their role, M2 macrophages independently stimulated with IL4, signal transducer and activator of transcription 6 (STAT6) and PPAR-coactivator-1 (PGC-1) engage an anti-inflammatory phenotype and rely on fatty acid oxidation (FAO) to generate ATP (42)

Furthermore, the observation that neurons show a higher number of ferroptosis DEGs in AD than astrocytes and oligodendrocytes suggests that ferroptosis affects neurons and glia cells differently (Kim et al., 2021)

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome