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Angiology 57:303311

Its effects require intact amylin receptor signaling, as demonstrated in receptor knockout models where weight loss is abolished, and structural studies show unique conformational dynamics at these receptors compared to native amylin or other analogs

Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

Atomoxetine, a selective norepinephrine reuptake inhibitor, improves short-term histological outcomes after hypoxic-ischemic brain injury in the neonatal male rat