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For example, while PS80-coated Poly lactic-co-glycolic acid (PLGA) NPs favoured cortical accumulation, the mechanisms involved in this targeting have yet to be elucidated
Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis
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