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Yang et al., An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1/NF-B cascade regulation of ROS scavenging and macrophage repolarization

In 18 young, sedentary, otherwise healthy subjects who participated in 8 weeks of heat therapy (hot water immersion to maintain rectal temperature 38.5C for 60 min per session) or thermoneutral water immersion, passive heat therapy was shown to improve cutaneous microvascular function by improving nitric oxide (NO)-dependent dilation [80]

Magnolol also show the potential to increase the activity or expression of ACE-2, and thus may aggravate SARS-CoV-2 infection (Junior et al., 2021)

EEC-1 exhibits elevated expression in pathways such as galactose metabolism, pantothenate and CoA metabolism, pyrimidine metabolism, and ROS detoxification
