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335 Quercetin, which targets the Bcl-2 family member hypoxia-inducible factor-1 (HIF-1) and the antiapoptotic PI3K/AKT and p21 signaling pathways, has demonstrated synergistic effects (Table 1)

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Perhaps the most clinically actionable finding is the strong association between disease trajectory and outcomes

ROS and Ca 2+ regulate the activity of the mitochondrial permeability transition pore (mPTP)
